
A transdiagnostic NIMHANS study involving 1,162 adults examined four temperament dimensions and adverse childhood experiences to understand psychiatric vulnerability.
Researchers found that schizophrenia and bipolar disorder were linked to lower extraversion and orienting sensitivity, whereas obsessive-compulsive disorder correlated with higher negative affectivity.
Childhood adversity significantly interacted with temperamental domains primarily in relation to alcohol use disorder among the examined cohort.