
Fanny Angelina Hesse proposed substituting liquefying gelatin with kitchen agar in Robert Koch's bacteriology laboratory in the 1880s to culture pathogens effectively.
Agar, a polysaccharide extracted from red algae containing agarose and agaropectin, remains thermally stable and solid at incubation temperatures required for human pathogen research.
The introduction of agar enabled scientists to reliably isolate pure bacterial colonies, facilitating foundational discoveries including identifying the tuberculosis bacillus.