
Researchers at the Johns Hopkins School of Medicine discovered that inherited traits in mice break Mendelian genetic rules due to chemical modifications of the genome.
The study, published in Nature Genetics on August 10, 2026, reveals that these modifications can jump across generations and change based on the sex of the animal.
These findings suggest that current genome-wide association studies may overlook significant heritable variation because they focus primarily on DNA sequences rather than these complex chemical changes.