New research indicates that major depressive disorders can dysregulate adult hippocampal neurogenesis, effectively blocking the brain's ability to grow new neurons.
The study, published in Nature, challenges previous assumptions about brain shrinkage, suggesting that the functional impairment of cell development is a key factor in depression.
These findings provide a new target for precision oncology and psychiatric treatments, potentially leading to therapies that can 'repair' the brain's regenerative capacity.