Functional Angiography Improves Outcomes in AIR-STEMI Trial

The AIR-STEMI trial of 1,823 patients found that functional coronary angiography significantly reduced cardiovascular events compared to conventional angiography in STEMI patients with multivessel disease.

At a median follow-up of 17.9 months, the primary endpoint occurred in 8.9% of the functional group versus 13.7% in the conventional group, with a hazard ratio of 0.62.

The functional approach reduced contrast-associated acute kidney injury or major bleeding to 4.6%, compared to 7.1% in the conventional group, according to findings presented at ESC Congress 2026.