Study Finds Neurogenesis Stalls in Depressed Adult Brains

Researchers at Columbia University found that neurogenesis stalls in the hippocampus of adults with major depressive disorder, potentially impairing emotional resilience.

The study analyzed nearly half a million brain cells from deceased donors to identify molecular changes in the trisynaptic circuit linked to depression.

Findings suggest that impaired pattern separation, caused by a lack of new neurons, may force patients to interpret current events through negative past memories.