Study Links Testosterone Levels to Atrial Fibrillation Risk

A review published in the Journal of the Endocrine Society suggests a non-linear association between testosterone levels and atrial fibrillation (AF) risk, with higher risks observed at both low and high levels.

Researchers analyzed data including the 2023 TRAVERSE trial and UK Biobank findings, proposing that the lowest AF risk occurs when total serum testosterone is between 350 and 550 ng/dL.

The study noted that while some evidence suggests testosterone replacement therapy (TRT) may increase AF hazards by up to 27%, findings remain inconsistent across various clinical trials and observational cohorts.