DNA-Based Therapy Reduces Bad Cholesterol by 50% in Mice

Researchers from the University of Barcelona and the University of Oregon developed a DNA-based therapy using polypurine hairpins that reduced bad cholesterol by 47% in transgenic mice.

A single injection of the HpE12 molecule decreased PCSK9 protein levels by 50% on the third day, according to findings published in the journal Biochemical Pharmacology.

The experimental treatment targets the PCSK9 gene to increase LDL receptor availability, offering a potential alternative to statins that researchers claim is stable and lacks immunogenicity.